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KMID : 0648320030090010037
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Journal of The Korean Society of Hypertension
2003 Volume.9 No. 1 p.37 ~ p.48
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The Efficacy and Safety of Cilnidipine in Patients with Essential Hypertension
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Hong Young-Joon
Jeong Myung-Ho
Kim Chung
Lee Gyung-Ok
Lim Sang-Chun
Lim Ji-Hyun
Park Hyung-Wook
Kim Han-Gyun
Park Ok-Young
Park Woo-Seok
Kim Ju-Han
Kim Weon
Ahn Young-Keun
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
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Abstract
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Background: Cilnidipine is a new and unique 1, 4-dihydropyridine calcium antagonist that has both L-type and
N-type voltage-dependent calcium channel blocking actions. The aim of this study is to confirm the therapeutic
efficacy and tolerance of cilnidipine (Cinalongⓡ) in patients with essential hypertension.
Methods: A total of 20 patients (57.7±11.6 years, male 40.0%) with essential hypertension whose systolic blood
pressure (SBP)≥160mmHg and/or diastolic blood pressure (DBP)≥95mmHg were enrolled. They received 10mg
cilnidipine once a day for 4 weeks, and if antihypertensive effect was inadequate, the dose was titrated up to 20
mg and administered for another 4 weeks.
Results: Two patients were dropped-out because of headache and abdominal pain. SBP, DBP and mean blood pressure were significantly decreased at 4 weeks after treatment and lasted constantly up to 8 weeks of treatment. Normalization of blood pressure was observed in 5 patients (27.8%) and effective decrease of blood pressure defined as either blood pressure less than 140/80mmHg or decrease of DBP more than 10mmHg was observed in 10 patients (55.6%).
Total number of effective antihypertensive effect was observed in 15 patients (83.3%). There were neither serious
adverse clinical and laboratory side effects during treatment. Electrocardiographic and echocardiographic indices for
left ventricular hypertrophy were not changed after the short course of clinidipine therapy.
Conclusions: Cilnidipine once a day is effective to control blood pressure without serious adverse effects in patients with essential hypertension.
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KEYWORD
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Hypertension, Ventricles, Hypertrophy, Calcium
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